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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are usually characterized by a focus on the practical aspects of the study design, including recruitment and consent as well as adherence to the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographic areas. This type of heterogeneity, which is vital for a pragmatic trial to be valid and lessen the chance of bias is also essential. However excessive heterogeneity could lead to issues with the design of the trial.

Pragmatic Play Pragmatic Play, a major player on the live casino market offers various classic table games such as Blackjack and Roulette. Pragmatic Play's live studios in Romania and Malta provide a genuine gambling experience for players and offer a wide range of virtual betting options. The company also has created various interactive games to make online gambling enjoyable. Some of these shows are telecast live and others include famous people from the field.

Mobile compatibility

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Pragmatic Play offers not only mobile-friendly slot machines but also live casino and table games. Pragmatic Play is licensed and is regulated by various regulatory bodies which include the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are protected by high-end encryption and its security staff is on hand to help players with any issues.

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Legality

Pragmatic Play has earned a name for itself by providing top-notch games and an exceptional user experience. Its software is designed to work with mobile devices and supports various languages. Despite its infancy it has established itself as a leading gaming platform for casinos. Its latest releases include Wolves which is a five-reel video slot that has a healthy RTP and 프라그마틱 정품확인 impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually requested by practitioners and policy makers to guide their decision-making. They can also be used to assess the causality of an intervention with its outcomes. They should, however, not be used to replace explanation studies.

The concept of pragmatism is controversial, and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also proposed an approach to pragmatic trials, dubbed PRECIS.2 This tool was designed to define the features of a pragmatic trial, including the recruitment process, the design and implementation of the intervention, as well as monitoring.

There is a positive trend in the number of pragmatic trials that are published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatism. It is important to remember that the majority of these studies were conducted in primary care settings.